Reference Report

Reference
Citation	Strunkelnberg, M., Bonengel, B., Moda, L.M., Hertenstein, A., de Couet, H.G., Ramos, R.G.P., Fischbach, K.F. (2001). rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila. Development 128(21): 4229--4239. (Export to RIS)
FlyBase ID	FBrf0139637
Publication Type	Research paper
PubMed ID	11684659
PubMed Abstract	The polynucleate myotubes of vertebrates and invertebrates form by fusion of myoblasts. We report the involvement of the Drosophila melanogaster Roughest (Rst) protein as a new membrane-spanning component in this process. Rst is strongly expressed in mesodermal tissues during embryogenesis, but rst null mutants display only subtle embryonic phenotypes. Evidence is presented that this is due to functional redundancy between Rst and its paralogue Kirre. Both are highly related single-pass transmembrane proteins with five extracellular immunoglobulin domains and three conserved motifs in the intracellular domain. The expression patterns of kirre and rst overlap during embryonic development in muscle founder cells. Simultaneous deletion of both genes causes an almost complete failure of fusion between muscle founder cells and fusion-competent myoblasts. This defect can be rescued by one copy of either gene. Moreover, Rst, like Kirre is a myoblast attractant.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(1)N-54l9 Df(1)w67k30
Alleles (9)
	Ecol\lacZ^kirre-rP298 Ecol\lacZ^{βTub56D.β1WHI} mbc^C1 N^fa-g rst⁶ rst^hs.18ZΔ3.1 rst^irreC1 rst^Scer\UAS.cSa Scer\GAL4^da.G32
Constructs (4)
	P{GAL4-da.G32} P{ha-rst.18ZΔ3.1} P{UAS-rst.(HB3)S} P{β1WHI}
Genes (7)
	Ecol\lacZ kirre mbc N rst Scer\GAL4 βTub56D
Insertions (3)
	flea{}N^fa-g P{}rst^irreC1 P{PZ}rP298
Transcripts (2)
	Ecol\lacZ^kirre-rP298RA Ecol\lacZ^{βTub56D.β1WHI}RA