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Reference Report
| Reference | |||
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| Citation | Ballestar, E., Pile, L.A., Wassarman, D.A., Wolffe, A.P., Wade, P.A. (2001). A Drosophila MBD family member is a transcriptional corepressor associated with specific genes. Europ. J. Biochem. 268(20): 5397--5406. (Export to RIS) | ||
| FlyBase ID | FBrf0139649 | ||
| Publication Type | Research paper | ||
| PubMed ID | 11606202 | ||
| PubMed Abstract | DNA methylation in Drosophila melanogaster is restricted temporally during development and occurs at a significantly lower frequency than in mammals. Thus, the regulatory functions, if any, of this form of DNA modification in Drosophila are unclear. However, the presence of homologs of vertebrate methyl-CpG-binding proteins implies functional consequences for DNA methylation in flies. This work describes the properties of dMBD-like, a Drosophila homolog of vertebrate MBD2 and MBD3. dMBD-like and dMBD-likeDelta (a splice variant) failed to bind model methylated DNA probes, inconsistent with their function as mediators of methyl CpG-directed transcriptional repression. However, the MBD-like proteins exhibit transcriptional and biochemical properties consistent with roles as components of a histone deacetylase-dependent corepressor complex similar to the vertebrate Mi-2 complex. The two proteins are differentially expressed during development, suggesting functional specialization. dMBD-like and/or dMBD-likeDelta is present at the chromocenter on larval polytene chromosomes as well as at discrete bands interspersed along the euchromatic chromosome arms, many of which are coincident with known ecdysone-induced loci. This banding pattern suggests gene-specific regulatory functions for dMBD-like and the Drosophila Mi-2 complex. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Europ. J. Biochem. | ||
| Title | European Journal of Biochemistry | ||
| Publication Year | 1967-2004 | ||
| ISBN/ISSN | 0014-2956 | ||
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Data from Reference
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| Alleles (5)
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| Genes (10)
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