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Citation
Rogina, B., Helfand, S.L. (2000). Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster.  Biogerontology 1(2): 163--169.
FlyBase ID
FBrf0141394
Publication Type
Research paper
Abstract

In the oxidative stress hypothesis of aging the random accumulation of oxidative damage over time is postulated to cause aging. The pace at which oxidative damage accrues determines the rate of aging, but it is less clear how the accumulation of random damage could cause the stereotypic pattern of aging. It has been proposed that oxidative damage induces changes in gene expression, translating a random input of damage into a patterned output. In support of this we show that in adult Drosophila melanogaster, with a deficiency in the anti-oxidant enzyme Cu, Zn superoxide dismutase (Sod), an increase in oxidative stress, and a shortened life span, there is acceleration in the normal age-related temporal pattern of wingless gene expression. The acceleration in the temporal pattern of wingless gene expression is proportional to the shortened life span suggesting that the shortened life span of Sod deficient animals is due, not to an abnormal pathological process, but to an increase in the rate of aging.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biogerontology
    Title
    Biogerontology
    Publication Year
    2000-
    ISBN/ISSN
    1389-5729
    Data From Reference
    Alleles (2)
    Genes (3)
    Insertions (1)