A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Reference Report

Reference
Citation Weiss, J.B., Suyama, K.L., Lee, H.H., Scott, M.P. (2001). Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation.  Cell 107(3): 387--398. (Export to RIS)
FlyBase ID FBrf0141412
Publication Type Research paper
PubMed ID 11701128
PubMed Abstract Inductive interactions subdivide the Drosophila mesoderm into visceral, somatic, and heart muscle precursors. The muscle precursors form organs by executing tissue-specific migrations and cell fusions. We identified a novel gene, jelly belly (jeb), which is required for visceral mesoderm development. jeb encodes a secreted protein that contains an LDL receptor repeat. In jeb mutants, visceral mesoderm precursors form, but they fail to migrate or differentiate normally; no visceral muscles develop. Jeb protein is produced in somatic muscle precursors and taken up by visceral muscle precursors. jeb reveals a signaling process in which somatic muscle precursors support the proper migration and differentiation of visceral muscle cells. Later in embryogenesis, jeb is transcribed in neurons and Jeb protein is found in axons.
DOI
Related Publication(s)
Review Jelly belly.
Anonymous, 2001, Science 294(5546): 1419 [FBrf0141819]

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Language of Publication English
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Publication Type Journal
Abbreviation Cell
Title Cell
Publication Year 1974-
ISBN/ISSN 0092-8674
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