Reference Report

Reference
Citation	Weiss, J.B., Suyama, K.L., Lee, H.H., Scott, M.P. (2001). Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation. Cell 107(3): 387--398. (Export to RIS)
FlyBase ID	FBrf0141412
Publication Type	Research paper
PubMed ID	11701128
PubMed Abstract	Inductive interactions subdivide the Drosophila mesoderm into visceral, somatic, and heart muscle precursors. The muscle precursors form organs by executing tissue-specific migrations and cell fusions. We identified a novel gene, jelly belly (jeb), which is required for visceral mesoderm development. jeb encodes a secreted protein that contains an LDL receptor repeat. In jeb mutants, visceral mesoderm precursors form, but they fail to migrate or differentiate normally; no visceral muscles develop. Jeb protein is produced in somatic muscle precursors and taken up by visceral muscle precursors. jeb reveals a signaling process in which somatic muscle precursors support the proper migration and differentiation of visceral muscle cells. Later in embryogenesis, jeb is transcribed in neurons and Jeb protein is found in axons.
DOI
Related Publication(s)
Review	Jelly belly. Anonymous, 2001, Science 294(5546): 1419 [FBrf0141819]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (16)
	Ecol\lacZ^Dr.A Ecol\lacZ^FragmentD Ecol\lacZ^ind.C Ecol\lacZ^jeb.B Ecol\lacZ^P\T.PC jeb^-c1 jeb^k05644 jeb^Scer\UAS.cWa jeb^unspecified Scer\GAL4^bap.3 Scer\GAL4^en-e16E Scer\GAL4^how-24B Scer\GAL4^twi.PG shi¹ tin^Scer\UAS.cWa w^+mC
Constructs (8)
	P{bap-GAL4.3} P{Dr-lacZ.A} P{FragmentD-lacZ} P{GAL4-twi.G} P{ind-lacZ.C} P{jeb-lacZ.B} P{UAS-jeb.W} P{UAS-tin.W}
Genes (17)
	bap Dr Ecol\lacZ en Fas3 grim ind jeb Mef2 Mhc peb rpr Scer\GAL4 shi tin w W
Insertions (3)
	P{en2.4-GAL4}e16E P{GawB}how^24B P{lacW}jeb^k05644
Transcripts (4)
	Ecol\lacZ^Dr.ARA Ecol\lacZ^jeb.BRA Scer\GAL4^bap.3RA Scer\GAL4^en-e16ERA