Reference Report

Reference
Citation	Yeh, E., Dermer, M., Commisso, C., Zhou, L., McGlade, C.J., Boulianne, G.L. (2001). Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr. Biol. 11(21): 1675--1679. (Export to RIS)
FlyBase ID	FBrf0141437
Publication Type	Research paper
PubMed ID	11696324
PubMed Abstract	The Notch pathway is a widely studied means of intercellular signaling responsible for the determination of cell fate, cell differentiation, and boundary formation (reviewed in ). The main effectors of this pathway, Notch (N) and Delta (Dl), have been shown to function as a receptor and ligand, respectively. Genetic and phenotypic studies suggest that Neuralized (Neu), a RING finger protein, also plays a role within the N-Dl pathway, although its biochemical function is unknown. Here, we show that Neu is required at the plasma membrane for functional activity and that its RING finger domain acts as an E3 ubiquitin ligase. These data suggest that the role of Neu is to target components of the N-Dl pathway for ubiquitination, allowing for propagation and/or regulation of the signal.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (11)
	neur¹¹ neur^{C701S.Scer\UAS.T:Hsap\MYC} neur^EMS1 neur^Scer\UAS.cYa neur^{Scer\UAS.T:Hsap\MYC} neur^{T22.Scer\UAS.T:Hsap\MYC} neur^{T42.Scer\UAS.T:Hsap\MYC} neur^unspecified Scer\GAL4^ptc-559.1 Scer\GAL4^sca-537.4 w^+mC
Constructs (5)
	P{UAS-neur.C701S} P{UAS-neur.Myc} P{UAS-neur.T22} P{UAS-neur.T42} P{UAS-neur.Y}
Genes (6)
	futsch neur Scer\GAL4 T:Hsap\MYC w β-Spec
Insertions (2)
	P{GawB}ptc^559.1 P{GawB}sca^537.4