Reference Report

Reference
Citation	Brown, S., Hu, N., Castelli-Gair Hombria, J. (2001). Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Curr. Biol. 11(21): 1700--1705. (Export to RIS)
FlyBase ID	FBrf0141438
Publication Type	Research paper
PubMed ID	11696329
PubMed Abstract	The JAK/STAT signaling pathway plays important roles in vertebrate development and the regulation of complex cellular processes. Components of the pathway are conserved in Dictyostelium, Caenorhabditis, and Drosophila, yet the complete sequencing and annotation of the D. melanogaster and C. elegans genomes has failed to identify a receptor, raising the possibility that an alternative type of receptor exists for the invertebrate JAK/STAT pathway. Here we show that domeless (dome) codes for a transmembrane protein required for all JAK/STAT functions in the Drosophila embryo. This includes its known requirement for embryonic segmentation and a newly discovered function in trachea specification. The DOME protein has a similar extracellular structure to the vertebrate cytokine class I receptors, although its sequence has greatly diverged. Like many interleukin receptors, DOME has a cytokine binding homology module (CBM) and three extracellular fibronectin-type-III domains (FnIII). Despite its low degree of overall similarity, key amino acids required for signaling in the vertebrate cytokine class I receptors [3] are conserved in the CBM region. DOME is a signal-transducing receptor with most similarities to the IL-6 receptor family, but it also has characteristics found in the IL-3 receptor family. This suggests that the vertebrate families evolved from a single ancestral receptor that also gave rise to dome.
DOI
Related Publication(s)
Review	Paper alert. Ligoxygakis, 2002, Trends Genet. 18(2): 72 [FBrf0145563]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(1)os^UE69
Alleles (18)
	dome^5.1 dome^G0217 dome^G0321 dome^G0367 dome^G0405 dome^G0441 dome^G0468 dome^{Scer\UAS.cCGHa} dome^unspecified dome^{ΔCYT.Scer\UAS} dome^{ΔTMCYT.Scer\UAS} hop^unspecified os^Scer\UAS.cZa os^UE69 Scer\GAL4^h-1J3 Scer\GAL4^klu-G410 Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} Stat92E⁰⁶³⁴⁶
Constructs (5)
	P{matα4-GAL-VP16} P{UAS-dome.CGH} P{UAS-dome.ΔCYT} P{UAS-dome.ΔTMCYT} P{UAS-os.Z}
Genes (10)
	dome eve hop kni os Scer\GAL4 Stat92E T:Hsim\VP16 trh vvl
Insertions (9)
	P{GAL4}klu^G410 P{GawB}h^1J3 P{lacW}dome^G0217 P{lacW}dome^G0321 P{lacW}dome^G0367 P{lacW}dome^G0405 P{lacW}dome^G0441 P{lacW}dome^G0468 P{UAS-dome.CGH}5.1