Reference Report

Reference
Citation	Ramain, P., Khechumian, K., Seugnet, L., Arbogast, N., Ackermann, C., Heitzler, P. (2001). Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr. Biol. 11(22): 1729--1738. (Export to RIS)
FlyBase ID	FBrf0141440
Publication Type	Research paper
PubMed ID	11719214
PubMed Abstract	The Notch receptor triggers a wide range of cell fate choices in higher organisms. In Drosophila, segregation of neural from epidermal lineages results from competition among equivalent cells. These cells express achaete/scute genes, which confer neural potential. During lateral inhibition, a single neural precursor is selected, and neighboring cells are forced to adopt an epidermal fate. Lateral inhibition relies on proteolytic cleavage of Notch induced by the ligand Delta and translocation of the Notch intracellular domain (NICD) to the nuclei of inhibited cells. The activated NICD, interacting with Suppressor of Hairless [Su(H)], stimulates genes of the E(spl) complex, which in turn repress the proneural genes achaete/scute.Here, we describe new alleles of Notch that specifically display loss of microchaetae sensory precursors. This phenotype arises from a repression of neural fate, by a Notch signaling distinct from that involved in lateral inhibition. We show that the loss of sensory organs associated with this phenotype results from a constitutive activation of a Deltex-dependent Notch-signaling event. These novel Notch alleles encode truncated receptors lacking the carboxy terminus of the NICD, which is the binding site for the repressor Dishevelled (Dsh). Dsh is known to be involved in crosstalk between Wingless and Notch pathways.Our results reveal an antineural activity of Notch distinct from lateral inhibition mediated by Su(H). This activity, mediated by Deltex (Dx), represses neural fate and is antagonized by elements of the Wingless (Wg)-signaling cascade to allow alternative cell fate choices.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(3R)gro^b32.2
Alleles (27)
	Dl^9P Dl^RevF10 Dl^unspecified dsh^hs.PA dx^ENU dx^P Ecol\lacZ^neur-A101 emc¹ gro^E48 N^Ax-9 N^Ax-59b N^Ax-E2 N^l1N-3 N^l1N-ts1 N^Mcd1 N^Mcd2 N^Mcd3 N^Mcd5 N^Mcd7 N^Mcd8 N^Mcd9 N^nd-3 N^spl-1 Ser^rev6-1 Ser^RX82 sgg³² Su(H)^IB115
Constructs (1)
	P{Hs:dsh}
Genes (12)
	ac Dl dsh dx Ecol\lacZ emc futsch gro N Ser sgg Su(H)
Insertions (1)
	P{lArB}neur^A101