Reference Report

Reference
Citation	Keisman, E.L., Christiansen, A.E., Baker, B.S. (2001). The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc. Dev. Cell 1(2): 215--225. (Export to RIS)
FlyBase ID	FBrf0141451
Publication Type	Research paper
PubMed ID	11702781
PubMed Abstract	Each Drosophila genital imaginal disc contains primordia for both male and female genitalia and analia. The sexually dimorphic development of this disc is governed by the sex-specific expression of doublesex (dsx). We present data that substantially revises our understanding of how dsx controls growth and differentiation in the genital disc. The classical view of genital disc development is that in each sex, dsx autonomously "represses" the development of the inappropriate genital primordium while allowing the development of the appropriate primordium. Instead, we show that dsx regulates the A/P organizer to control growth of each genital primordium, and then directs each genital primordium to differentiate defined adult structures in both sexes.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (9)
	Avic\GFP^{S65T.Scer\UAS} Avic\GFP^{Scer\UAS.T:SV40\nls2} Ecol\lacZ^en-Xho25 Scer\GAL4^cad-md509 Scer\GAL4^en-e16E Scer\GAL4^esg-05730B Scer\GAL4^ptc-559.1 tra2^{dsRNA.Scer\UAS} tra^Scer\UAS.cFa
Constructs (4)
	P{UAS-GFP.nls} P{UAS-GFP.S65T} P{UAS-tra2.IR} P{UAS-tra.F}
Genes (7)
	Avic\GFP Ecol\lacZ Scer\GAL4 Sxl T:SV40\nls2 tra tra2
Insertions (5)
	P{en2.4-GAL4}e16E P{en-lacZ(Xho)}en^Xho25 P{GawB}05730B P{GawB}cad^md509 P{GawB}ptc^559.1