Reference Report

Reference
Citation	Georgel, P., Naitza, S., Kappler, C., Ferrandon, D., Zachary, D., Swimmer, C., Kopczynski, C., Duyk, G., Reichhart, J.M., Hoffmann, J.A. (2001). Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev. Cell 1(4): 503--514. (Export to RIS)
FlyBase ID	FBrf0141455
Publication Type	Research paper
PubMed ID	11703941
PubMed Abstract	We report the molecular characterization of the immune deficiency (imd) gene, which controls antibacterial defense in Drosophila. imd encodes a protein with a death domain similar to that of mammalian RIP (receptor interacting protein), a protein that plays a role in both NF-kappaB activation and apoptosis. We show that imd functions upstream of the DmIKK signalosome and the caspase DREDD in the control of antibacterial peptide genes. Strikingly, overexpression of imd leads to constitutive transcription of these genes and to apoptosis, and both effects are blocked by coexpression of the caspase inhibitor P35. We also show that imd is involved in the apoptotic response to UV irradiation. These data raise the possibility that antibacterial response and apoptosis share common control elements in Drosophila.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (6)
	Df(2R)1.1 Df(2R)1.2 Df(2R)2.1 Df(2R)2.2 Df(2R)2.3 Df(2R)C5
Alleles (15)
	BacA\p35^Scer\UAS.cHa Dredd^D55 Ecol\lacZ^Dpt.PR Ecol\lacZ^rpr.11 imd^{1.Act5C.T:Hsap\MYC,T:Ivir\HA1} imd¹ imd^+t5.1 imd^{Act5C.T:Hsap\MYC,T:Ivir\HA1} imd^Scer\UAS.cGa key¹ Ppyr\LUC^AttA.PT Ppyr\LUC^Dro.PT Scer\GAL4^da.G32 Scer\GAL4^hs.PB Scer\GAL4^yolk
Constructs (7)
	P{Dipt2.2-lacZ} P{GAL4-da.G32} P{imd^+t5.1} P{rpr-lacZ.R.11} P{UAS-imd.G} P{UAS-p35.H} P{yolk-GAL4}
Genes (19)
	AttA AttB AttC AttD BacA\p35 CecA1 Dpt Dredd Dro Drs Ecol\lacZ imd ird5 key Mtk Ppyr\LUC Scer\GAL4 T:Hsap\MYC T:Ivir\HA1
Insertions (2)
	P{lacW}l(2)08770^k04808 P{lacW}VG(2)A