Reference Report

Reference
Citation	Hidalgo, A., Kinrade, E.F., Georgiou, M. (2001). The Drosophila neuregulin vein maintains glial survival during axon guidance in the CNS. Dev. Cell 1(5): 679--690. (Export to RIS)
FlyBase ID	FBrf0141461
Publication Type	Research paper
PubMed ID	11709188
PubMed Abstract	Neuron-glia interactions are necessary for the formation of the longitudinal axon trajectories in the Drosophila central nervous system. Longitudinal glial cells are required for axon guidance and fasciculation, and pioneer neurons for trophic support of the glia. Neuregulin is a neuronal molecule that controls glial survival in the vertebrate nervous system. The Drosophila protein Vein has structural similarities with Neuregulin. We show here that Vein functions like a Neuregulin to maintain glial cell survival. We present direct in vivo evidence at single-cell resolution that Vein is produced by pioneer neurons and maintains the survival of neighboring longitudinal glia. This mechanism links axon guidance to control of glial cell number and may contribute to plasticity during the establishment of normal axonal trajectories.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (2)
	Df(3L)H99 Df(3L)γ3
Alleles (18)
	Avic\GFP^{Scer\UAS.T:Hsap\Myr2} BacA\p35^Scer\UAS.cHa Egfr^DN.Scer\UAS Egfr^f24 Egfr^tsla Ras85D^N17.Scer\UAS Rcom\RA^Scer\UAS.cSa Scer\GAL4^15J2 Scer\GAL4^ap-md544 Scer\GAL4^elav.PLu Scer\GAL4^ftz.ng Scer\GAL4^htl.POS Scer\GAL4^s.gcm spi¹ vn^as.Scer\UAS vn^{dsRNA.Scer\UAS} vn^Scer\UAS.cSa vn^γ4
Constructs (12)
	P{GAL4-elav.L} P{GAL4-ftz.ng} P{GAL4-htl.OS} P{sgcm-GAL4} P{UAS-Egfr.DN} P{UAS-gapGFP} P{UAS-p35.H} P{UAS-RA} P{UAS-Ras85D.N17} P{UAS-vn.as} P{UAS-vn.dsRNA} P{UAS-vn.S}
Genes (10)
	Avic\GFP BacA\p35 Egfr gcm Ras85D Rcom\RA Scer\GAL4 spi T:Hsap\Myr2 vn
Insertions (3)
	P{GAL4}md52 P{GawB}ap^md544 P{sgcm-GAL4}151