Reference Report

Reference
Citation	Sudarsan, V., Anant, S., Guptan, P., VijayRaghavan, K., Skaer, H. (2001). Myoblast diversification and ectodermal signaling in Drosophila. Dev. Cell 1(6): 829--839. (Export to RIS)
FlyBase ID	FBrf0141467
Publication Type	Research paper
PubMed ID	11740944
PubMed Abstract	The flight muscles of Drosophila derive from myoblasts found on the third instar disc. We demonstrate that these myoblasts already show distinctive properties and examine how this diversity is generated. In the late larva, Vestigial and low levels of Cut are expressed in myoblasts that will contribute to the indirect flight muscles. Other myoblasts, which express high levels of Cut but no Vestigial, are required for the formation of the direct flight muscles. Vestigial and Cut expression are stabilized by a mutually repressive feedback loop. Vestigial expression begins in the embryo in a subset of adult myoblasts, and Wingless signaling is required later to maintain this expression. Thus, myoblasts are divided into identifiable populations, consistent with their allocation to different muscles, and ectodermal signals act to maintain these differences.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Alleles (11)
	arm^{S10.Scer\UAS.T:Hsap\MYC} ct^Scer\UAS.cLa dsh³ Ecol\lacZ^twi.1.4a fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} pan^ΔN.Scer\UAS Scer\GAL4¹¹⁵¹ vg¹ vg^83b27-R vg^Scer\UAS.cKa wg^l-12
Constructs (6)
	P{twi-βgal-1.4a} P{UAS-arm.S10} P{UAS-ct.L} P{UAS-fz2(ECD)-GPI} P{UAS-pan.dTCFΔN} P{UAS-vg.K}
Genes (12)
	arm ct dsh Ecol\lacZ fz2 Mef2 pan Scer\GAL4 T:Hsap\MYC twi vg wg
Insertions (1)
	P{GAL4}1151
Transcripts (1)
	Ecol\lacZ^twi.1.4aRA