Reference Report

Reference
Citation	Hu, Y., Ye, Y., Fortini, M.E. (2002). Nicastrin Is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2(1): 69--78. (Export to RIS)
FlyBase ID	FBrf0141470
Publication Type	Research paper
PubMed ID	11782315
PubMed Abstract	Nicastrin is genetically linked to Notch/lin-12 signaling in C. elegans and is part of a large multiprotein complex along with Presenilin. Here we describe the isolation and characterization of Drosophila Nicastrin (Nic) mutants. Nic mutants and tissue clones display characteristic Notch-like phenotypes. Genetic and inhibitor studies indicate a function for Nicastrin in the gamma-secretase step of Notch processing, similar to Presenilin. Further, Nicastrin is genetically required for signaling from membrane-anchored activated Notch. In the absence of Nicastrin, Presenilin is destabilized and mature C-terminal subunits are absent. Nicastrin might recruit gamma-secretase substrates into the proteolytic complex as a prerequisite for Presenilin maturation and active complex assembly.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(3R)96B
Alleles (15)
	Ecol\lacZ^sca-A2-6 kuz^DN.hs N^ECN.hs N^int.hs N^ΔECN.hs nct^A7 nct^D329A.Y330A nct^dsRNA.cHa nct^E3 nct^J1 nct^J2 nct^Δ304-333 nct^Δ607-637 Psn^dsRNA.cHa Su(H)^dsRNA.cHa
Constructs (3)
	P{hs/KUZDN} P{hsp70-Notch.intra} P{ΔECN}
Genes (7)
	Ecol\lacZ elav kuz N nct Psn Su(H)
Insertions (1)
	P{lacW}sca^A2-6