|Citation||Hu, Y., Ye, Y., Fortini, M.E. (2002). Nicastrin Is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2(1): 69--78. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Nicastrin is genetically linked to Notch/lin-12 signaling in C. elegans and is part of a large multiprotein complex along with Presenilin. Here we describe the isolation and characterization of Drosophila Nicastrin (Nic) mutants. Nic mutants and tissue clones display characteristic Notch-like phenotypes. Genetic and inhibitor studies indicate a function for Nicastrin in the gamma-secretase step of Notch processing, similar to Presenilin. Further, Nicastrin is genetically required for signaling from membrane-anchored activated Notch. In the absence of Nicastrin, Presenilin is destabilized and mature C-terminal subunits are absent. Nicastrin might recruit gamma-secretase substrates into the proteolytic complex as a prerequisite for Presenilin maturation and active complex assembly.|
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|Language of Publication||English|
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