Reference Report

Reference
Citation	Shim, K., Blake, K.J., Jack, J., Krasnow, M.A. (2001). The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis. Development 128(23): 4923--4933. (Export to RIS)
FlyBase ID	FBrf0141499
Publication Type	Research paper
PubMed ID	11731471
PubMed Abstract	During development of the Drosophila tracheal (respiratory) system, the cell bodies and apical and basal surfaces of the tracheal epithelium normally move in concert as new branches bud and grow out to form tubes. We show that mutations in the Drosophila ribbon (rib) gene disrupt this coupling: the basal surface continues to extend towards its normal targets, but movement and morphogenesis of the tracheal cell bodies and apical surface is severely impaired, resulting in long basal membrane protrusions but little net movement or branch formation. rib mutant tracheal cells are still responsive to the Branchless fibroblast growth factor (FGF) that guides branch outgrowth, and they express apical membrane markers normally. This suggests that the defect lies either in transmission of the FGF signal from the basal surface to the rest of the cell or in the apical cell migration and tubulogenesis machinery. rib encodes a nuclear protein with a BTB/POZ domain and Pipsqueak DNA-binding motif. It is expressed in the developing tracheal system and other morphogenetically active epithelia, many of which are also affected in rib mutants. We propose that Rib is a key regulator of epithelial morphogenesis that promotes migration and morphogenesis of the tracheal cell bodies and apical surface and other morphogenetic movements.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (4)
	Df(2R)ena^GC8 Df(2R)P34 Df(2R)PC29 Df(2R)rib-ex12
Alleles (16)
	bnl⁰⁰⁸⁵⁷ bnl^Scer\UAS.cSa cora² cora^k08713 Ecol\lacZ^trh-1-eve-1 ena^1-8 ena⁸⁷ ena^GC1 prod^k08810 rib¹ rib² rib^P7 rib^P16 rib^P34 rib^z1 Scer\GAL4^69B
Constructs (1)
	P{UAS-bnl.S}
Genes (23)
	5-HT1A bab1 bnl br bs btl CG7229 CG10737 CG11906 CG16778 cora crb Ecol\lacZ ena lola prod psq rib rl Scer\GAL4 Tab2 ttk wbl
Insertions (3)
	P{ET-L}trh-1-eve-1 P{GawB}69B P{lacZ}Terminal-3