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Reference
Citation	Ruiz-Gomez, M., Coutts, N., Suster, M.L., Landgraf, M., Bate, M. (2002). myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila. Development 129(1): 133--141.
FlyBase ID	FBrf0141504
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	11782407
PubMed Abstract	We report a new gene, myoblasts incompetent, essential for normal myogenesis and myoblast fusion in Drosophila. myoblasts incompetent encodes a putative zinc finger transcription factor related to vertebrate Gli proteins and to Drosophila Cubitus interruptus. myoblasts incompetent is expressed in immature somatic and visceral myoblasts. Expression is predominantly in fusion-competent myoblasts and a loss-of-function mutation in myoblasts incompetent leads to a failure in the normal differentiation of these cells and a complete lack of myoblast fusion. In the mutant embryos, founder myoblasts differentiate normally and form mononucleate muscles, but genes that are specifically expressed in fusion-competent cells are not activated and the normal downregulation of twist expression in these cells fails to occur. In addition, fusion-competent myoblasts fail to express proteins characteristic of the general pathway of myogenesis such as myosin and Dmef2. Thus myoblasts incompetent appears to function specifically in the general pathway of myogenesis to control the differentiation of fusion-competent myoblasts.
Biosis	2002.319180
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Language of publication	English
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Abbreviation	Development
Title	Development
Authors
Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Aberrations (9)
	Df(3R)23D1 Df(3R)5C1 Df(3R)Dl-FX3 Df(3R)EB6 Df(3R)M95A Df(3R)hh Df(3R)hh-GW2 Df(3R)hhE23 Df(3R)r90b
Alleles (11)
	Ecol\lacZ^kirre-rP298 Mef2^III.Scer\UAS N^55e11 Scer\GAL4^en-e16E Scer\GAL4^sca.PC Scer\GAL4^twi.PB lmd^A388 lmd^Scer\UAS.cRa mbc^C1 twi¹ w^+mC
Constructs (4)
	P{GAL4-twi.B} P{UAS-Mef2.III} P{UAS-lmd.R} P{sca-Gal-4}
Genes (15)
	CG31365 Ecol\lacZ Kr Mef2 Mhc N Scer\GAL4 ca e h lmd mbc sns twi w
Insertions (2)
	P{PZ}rP298 P{en2.4-GAL4}e16E