Reference Report

Reference
Citation	Nagel, A.C., Wech, I., Preiss, A. (2001). scalloped and strawberry notch are target genes of Notch signaling in the context of wing margin formation in Drosophila. Mech. Dev. 109(2): 241--251. (Export to RIS)
FlyBase ID	FBrf0141638
Publication Type	Research paper
PubMed ID	11731237
PubMed Abstract	The Notch pathway regulates the differentiation of many cell types throughout development of higher metazoa. Different cellular responses are elicited through specific activation of distinct Notch target genes. In the Drosophila wing, for example, the cut gene is activated by Notch signaling along the dorso-ventral boundary but, as we show here, not in other cell types. We identify additional regulatory components, scalloped and strawberry notch, that are targets of the Notch pathway specifically within the wing anlagen. As suggested by physical interactions, these proteins could be co-factors of the cut trans-regulator Vestigial. Additional regulatory input comes from the Wingless pathway. Our data support a model, whereby context specific involvement of distinct co-regulators modulates Notch target gene activation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (13)
	Ecol\lacZ^sd-ETX4 Ecol\lacZ^vg.806 Ecol\lacZ^vg.int2.1 N^{int.G.Scer\UAS} Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^en-e16E Scer\GAL4^prd.RG1 Scer\GAL4^ptc-559.1 Su(H)⁸ Su(H)^Scer\UAS.cNa Su(H)^{Scer\UAS.T:Hsap\MYC,T:Hsim\VP16} wg^Scer\UAS.cLa
Constructs (7)
	P{GAL4-prd.F} P{UAS-N.intra.G} P{UAS-Su(H).N} P{UAS-Su(H).VP16} P{UAS-wg.L} P{vg(806)-lacZ} P{vg(D/V)-lacZ}
Genes (10)
	ct Ecol\lacZ N Scer\GAL4 sno Su(H) T:Hsap\MYC T:Hsim\VP16 vg wg
Insertions (6)
	P{en2.4-GAL4}e16E P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}ptc^559.1 P{lArB}sd^ETX4 P{UAS-Su(H).N}5-8