Reference Report

Reference
Citation	Suh, G.S., Poeck, B., Chouard, T., Oron, E., Segal, D., Chamovitz, D.A., Zipursky, S.L. (2002). Drosophila JAB1/CSN5 Acts in Photoreceptor Cells to Induce Glial Cells. Neuron 33(1): 35--46. (Export to RIS)
FlyBase ID	FBrf0141691
Publication Type	Research paper
PubMed ID	11779478
PubMed Abstract	Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye form connections in different optic ganglia. The R1-R6 subclass connects to the first optic ganglion, the lamina, and relies upon glial cells as intermediate targets. Conversely, R cells promote glial cell development including migration of glial cells into the target region. Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration. In these CSN5 alleles, R1-R6 targeting is disrupted. Genetic analysis of protein null alleles further revealed that the COP9 signalosome is required at an earlier stage of development for R cell differentiation.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (2)
	Df(3R)RK6-3 Df(3R)sbd104
Alleles (17)
	CSN4^k08018 CSN4^N CSN5^+t6.6 CSN5^+t30 CSN5^+tSa CSN5^hs.PS CSN5^L4032 CSN5^N CSN5^quo-1 CSN5^quo-2 CSN5^quo-3 CSN5^Scer\UAS.cSa CSN5^T:Hsap\MYC CSN5^unspecified Ecol\lacZ^{ninaE.-252+67} Ecol\lacZ^{ro.T:Btau\MAPT} Scer\GAL4^elav.PLu
Constructs (9)
	P{CSN5.genomic.T:Hsap\MYC} P{CSN5.genomic} P{CSN5^+t6.6} P{CSN5^+tSa} P{GAL4-elav.L} P{hs-CSN5.S} P{Rh1-lacZ} P{ro.lacZ-tau.G} P{UAS-CSN5.S}
Genes (15)
	B boss chp ci CSN4 CSN5 dac Ecol\lacZ elav futsch pros repo Scer\GAL4 T:Btau\MAPT T:Hsap\MYC
Insertions (2)
	P{lacW}CSN4^k08018 P{lacW}CSN5^L4032