|Citation||Kiger, A.A., Jones, D.L., Schulz, C., Rogers, M.B., Fuller, M.T. (2001). Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science 294(5551): 2542--2545. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population.|
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|Language of Publication||English|
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