Open Close
Reference
Citation
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., Tuschl, T. (2001). Identification of novel genes coding for small expressed RNAs.  Science 294(5543): 853--858.
FlyBase ID
FBrf0141757
Publication Type
Research paper
Abstract

In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.

PubMed ID
PubMed Central ID
Related Publication(s)
Supplementary material
Note

Molecular biology: glimpses of a tiny RNA world.
Ruvkun, 2001, Science 294(5543): 797--799 [FBrf0141756]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference