Reference Report

Reference
Citation	Bergmann, A., Tugentman, M., Shilo, B.Z., Steller, H. (2002). Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. Dev. Cell 2(2): 159--170. (Export to RIS)
FlyBase ID	FBrf0144794
Publication Type	Research paper
PubMed ID	11832242
PubMed Abstract	Trophic mechanisms in which neighboring cells mutually control their survival by secreting extracellular factors play an important role in determining cell number. However, how trophic signaling suppresses cell death is still poorly understood. We now show that the survival of a subset of midline glia cells in Drosophila depends upon direct suppression of the proapoptotic protein HID via the EGF receptor/RAS/MAPK pathway. The TGFalpha-like ligand SPITZ is activated in the neurons, and glial cells compete for limited amounts of secreted SPITZ to survive. In midline glia that fail to activate the EGFR pathway, HID induces apoptosis by blocking a caspase inhibitor, Diap1. Therefore, a direct pathway linking a specific extracellular survival factor with a caspase-based death program has been established.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (2)
	Df(2R)rl10a Df(3L)H99
Alleles (23)
	comm^Δe39 Ecol\lacZ^sli.1.0HV Ecol\lacZ^sty-s2683 Egfr^DN.Scer\UAS Egfr^f2 rho^Scer\UAS.cGa rl^AL528 rl^Sem rl^unspecified S^Scer\UAS.cGa Scer\GAL4^elav.PLu Scer\GAL4^hs.PB Scer\GAL4^sim.PS Scer\GAL4^sli.PS spi¹ spi³ spi^s.Scer\UAS spi^Scer\UAS.cSa W^{Ala5.Scer\UAS} W^hid-A329 W^rvX1 W^Scer\UAS.cZa W^unspecified
Constructs (12)
	P{GAL4-elav.L} P{GAL4-Hsp70.PB} P{GAL4-sim.S} P{GAL4-sli.S} P{sli(1.0)-lacZ} P{UAS-Egfr.DN} P{UAS-spi.m} P{UAS-spi.s} P{UAS-Star} P{UAS-ve.(rho)G} P{UAS-W.Ala5} P{UAS-W.Z}
Genes (11)
	comm Ecol\lacZ Egfr rho rl S Scer\GAL4 sli spi sty W
Insertions (3)
	P{lacW}s2683 P{UAS-spi.m}7b P{UAS-spi.s}4a
Transcripts (2)
	Ecol\lacZ^sli.1.0HVRA Ecol\lacZ^sty-s2683RA