Reference Report

Reference
Citation	Nabel-Rosen, H., Volohonsky, G., Reuveny, A., Zaidel-Bar, R., Volk, T. (2002). Two isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation. Dev. Cell 2(2): 183--193. (Export to RIS)
FlyBase ID	FBrf0144795
Publication Type	Research paper
PubMed ID	11832244
PubMed Abstract	Differential RNA metabolism regulates a wide array of developmental processes. Here, we describe a mechanism that controls the transition from premature Drosophila tendon precursors into mature muscle-bound tendon cells. This mechanism is based on the opposing activities of two isoforms of the RNA binding protein How. While the isoform How(L) is a negative regulator of Stripe, the key modulator of tendon cell differentiation, How(S) isoform elevates Stripe levels, thereby releasing the differentiation arrest induced by How(L). The opposing activities of the How isoforms are manifested by differential rates of mRNA degradation of the target stripe mRNA. This mechanism is conserved, as the mammalian RNA binding Quaking proteins may similarly affect the levels of Krox20, a regulator of Schwann cell maturation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (11)
	Avic\GFP^Scer\UAS.cUa Avic\GFP^{sr.3'UTR.Scer\UAS} how^e44 how^L.Scer\UAS how^S.Scer\UAS Scer\GAL4^en-e16E Scer\GAL4^sr-md710 Scer\GAL4^tub.PU sr^{B-3'UTR.Scer\UAS} sr^B.Scer\UAS w^+mC
Constructs (7)
	P{tub-GAL4.U} P{UAS-GFP.sr3'UTR} P{UAS-GFP.U} P{UAS-how.L} P{UAS-how.S} P{UAS-sr.B-3'UTR} P{UAS-sr.isoB}
Genes (5)
	Avic\GFP how Scer\GAL4 sr w
Insertions (2)
	P{en2.4-GAL4}e16E P{GawB}sr^md710
Natural transposons (1)
	P-element