Reference Report

Reference
Citation	Streit, A., Kohler, R., Marty, T., Belfiore, M., Takacs-Vellai, K., Vigano, M.A., Schnabel, R., Affolter, M., Muller, F. (2002). Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13. Dev. Biol. 242(2): 96--108. (Export to RIS)
FlyBase ID	FBrf0144802
Publication Type	Research paper
PubMed ID	11820809
PubMed Abstract	Caenorhabditis elegans contains a set of six cluster-type homeobox (Hox) genes that are required during larval development. Some of them, but unlike in flies not all of them, are also required during embryogenesis. It has been suggested that the control of the embryonic expression of the worm Hox genes might differ from that of other species by being regulated in a lineal rather than a regional mode. Here, we present a trans-species analysis of the cis-regulatory region of ceh-13, the worm ortholog of the Drosophila labial and the vertebrate Hox1 genes, and find that the molecular mechanisms that regulate its expression may be similar to what has been found in species that follow a regulative, non-cell-autonomous mode of development. We have identified two enhancer fragments that are involved in different aspects of the embryonic ceh-13 expression pattern. We show that important features of comma-stage expression depend on an autoregulatory input that requires ceh-13 and ceh-20 functions. Our data show that the molecular nature of Hox1 class gene autoregulation has been conserved between worms, flies, and vertebrates. The second regulatory sequence is sufficient to drive correct early embryonic expression of ceh-13. Interestingly, this enhancer fragment acts as a response element of the Wnt/WG signaling pathway in Drosophila embryos.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (12)
	arm^{S10.Scer\UAS.T:Hsap\MYC} Ecol\lacZ^{Cele\ceh-13.enh1.2} Ecol\lacZ^{Cele\ceh-13.enh3.4} Ecol\lacZ^{Cele\ceh-13.enh4.6} Ecol\lacZ^{Cele\ceh-13.enh450} Ecol\lacZ^{Cele\ceh-13.enh740} pan² pan^ΔN.Scer\UAS Scer\GAL4^48Y Scer\GAL4^how-24B Scer\GAL4^prd.RG1 wg^l-17
Constructs (8)
	P{ceh-13-lacZ.enh1.2} P{ceh-13-lacZ.enh3.4} P{ceh-13-lacZ.enh4.6} P{ceh-13-lacZ.enh450} P{ceh-13-lacZ.enh740} P{GAL4-prd.F} P{UAS-arm.S10} P{UAS-pan.dTCFΔN}
Genes (8)
	arm dpp Ecol\lacZ lab pan Scer\GAL4 T:Hsap\MYC wg
Insertions (2)
	P{GawB}48Y P{GawB}how^24B