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Reference
Citation	Fetchko, M., Huang, W., Li, Y., Lai, Z.C. (2002). Drosophila Gp150 is required for early ommatidial development through modulation of Notch signaling. EMBO J. 21(5): 1074--1083.
FlyBase ID	FBrf0144849
Type of publication	Research paper
Offprint Available	No
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PubMed ID	11867535
PubMed Abstract	Cellular signaling activities must be tightly regulated for proper cell fate control and tissue morphogenesis. Here we report that the Drosophila leucine-rich repeat transmembrane glycoprotein Gp150 is required for viability, fertility and development of the eye, wing and sensory organs. In the eye, Gp150 plays a critical role in regulating early ommatidial formation. Gp150 is highly expressed in cells of the morphogenetic furrow (MF) region, where it accumulates exclusively in intracellular vesicles in an endocytosis-independent manner. Loss of gp150 function causes defects in the refinement of photoreceptor R8 cells and recruitment of other cells, which leads to the formation of aberrant ommatidia. Genetic analyses suggest that Gp150 functions to modulate Notch signaling. Consistent with this notion, Gp150 is co-localized with Delta in intracellular vesicles in cells within the MF region and loss of gp150 function causes accumulation of intracellular Delta protein. Therefore, Gp150 might function in intracellular vesicles to modulate Delta-Notch signaling for cell fate control and tissue morphogenesis.
Biosis	2002.231958
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Language of publication	English
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Abbreviation	EMBO J.
Title	The EMBO Journal
Authors
Volume range	1-
Year range	1982-
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Publisher
Place of publication	Oxford
Language of publication	English
ISBN/ISSN	0261-4189
CODEN	EMJODG
Data from Reference
Aberrations (1)
	Df(2R)02311
Alleles (27)
	Dl^6B Dl^9P Dl^MtnA.PF Gp150³ Gp150⁴ Gp150^GMR.PF Gp150^{MtnA.6x.T:Hsap\MYC} Gp150^P10 Gp150^P11 Gp150^P12 Gp150^P13 Gp150^P15 Gp150^P16 Gp150^P2 Gp150^P6 Gp150^P8 Gp150^k11107b Gp150^k11120b Gp150^unspecified N^55e11 Rab7^{Scer\UAS.T:Avic\GFP} Ras85D^V12.sev Ras85D^e1B Ras85D^e2F fng^{ADD.Scer\UAS.T:Hsap\MYC} rl^S-135 shi¹
Constructs (4)
	P{GMR-Gp150.F} P{UAS-ADD-fng.MYC} P{UAS-Rab7.GFP} P{sevRas1.V12}
Genes (17)
	B Dl Gp150 N Rab7 Ras85D T:Avic\GFP T:Hsap\MYC ato boss ct dpp elav fng h rl shi
Insertions (10)
	P{lacW}Gp150^P10 P{lacW}Gp150^P11 P{lacW}Gp150^P12 P{lacW}Gp150^P13 P{lacW}Gp150^P15 P{lacW}Gp150^P16 P{lacW}Gp150^P2 P{lacW}Gp150^P6 P{lacW}Gp150^P8 P{lacW}px^k08134