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Reference Report
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| Citation | Okada, M., Akimaru, H., Hou, D.X., Takahashi, T., Ishii, S. (2002). Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 21(4): 675--684. (Export to RIS) | ||
| FlyBase ID | FBrf0144853 | ||
| Publication Type | Research paper | ||
| External Crossreferences | |||
| PubMed ID | 11847115 | ||
| PubMed Abstract | The c-myb proto-oncogene product (c-Myb) is a transcriptional activator. Vertebrate c-Myb is a key regulator of the G(1)/S transition in cell cycle, while Drosophila Myb (dMyb) is important for the G(2)/M transition. Here we report that dMyb induces expression of cyclin B, a critical regulator of the G(2)/M transition, in Drosophila eye imaginal disc. In the wild-type eye disc, dmyb mRNA was expressed in the stripes both anterior and posterior to the morphogenetic furrow. Ectopic expression of C-terminal-truncated dMyb in the eye disc caused ectopic expression of cyclin B and the rough eye phenotype. This rough eye phenotype correlated with prolonged M phase, caused by overexpression of cyclin B. Cyclin B expression was lost in dmyb-deficient clones. In Schneider cells, the activity of the cyclin B promoter was dramatically reduced by loss of dMyb using the RNA interference method. Mutations of the multiple AACNG sequences in the cyclin B promoter also abolished the promoter activity. These results indicate that dMyb regulates the G(2)/M transition by inducing cyclin B expression via binding to its promoter. | ||
| BIOSIS ID | 2002.208143 | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | EMBO J. | ||
| Title | The EMBO Journal | ||
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| Publication Year | 1982- | ||
| ISBN/ISSN | 0261-4189 | ||
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Data from Reference
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| Alleles (15)
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| Constructs (5)
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| Genes (9)
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