Reference Report

Reference
Citation	Wang, J., Zugates, C.T., Liang, I.H., Lee, C.H., Lee, T. (2002). Drosophila dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron 33(4): 559--571. (Export to RIS)
FlyBase ID	FBrf0145178
Publication Type	Research paper
PubMed ID	11856530
PubMed Abstract	Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies. Single axon analysis further reveals that Dscam mutant axons generate additional branches, which randomly segregate among the available targets. Moreover, when only one target remains, branching is suppressed in wild-type axons while Dscam mutant axons still form multiple branches at the original bifurcation point. Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (7)
	Dscam¹ Dscam¹⁸ Dscam⁰⁵⁵¹⁸ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^EB1 Scer\GAL4^ey-OK107 Scer\GAL4^Tab2-201Y
Constructs (1)
	P{UAS-mCD8::GFP.L}
Genes (5)
	Dscam Fas2 Mmus\Cd8a Scer\GAL4 T:Avic\GFP
Insertions (4)
	P{GawB}EB1 P{GawB}ey^OK107 P{GawB}Tab2^201Y P{PZ}Dscam⁰⁵⁵¹⁸