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Reference Report
| Reference | |||
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| Citation | Kang, H.L., Benzer, S., Min, K.T. (2002). Life extension in Drosophila by feeding a drug. Proc. Natl. Acad. Sci. U.S.A. 99(2): 838--843. (Export to RIS) | ||
| FlyBase ID | FBrf0145208 | ||
| Publication Type | Research paper | ||
| PubMed ID | 11792861 | ||
| PubMed Abstract | We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state. | ||
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| FB2013_03 | |||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Proc. Natl. Acad. Sci. U.S.A. | ||
| Title | Proceedings of the National Academy of Sciences of the United States of America | ||
| Publication Year | 1915- | ||
| ISBN/ISSN | 0027-8424 | ||
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Data from Reference
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| Genes (26)
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