Reference Report

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Citation	Osterwalder, T. (2002.3.25). Helping FlyBase: ADRC-10845. (Export to RIS)
FlyBase ID	FBrf0146814
Publication Type	Personal communication to FlyBase
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Text of Personal Communication	From rd120@XXXXXXXXXXXXXXX Mon Mar 18 09:37:50 2002 To: thomas.osterwalder@XXXXXXXXXXXXXXX Subject: Helping FlyBase: ADRC-10845 Dear Thomas, We are currently curating the abstracts for the upcoming 43rd (San Diego) Annual Drosophila Research Conference, for FlyBase. I am writing in connection with your abstract: 'Neuroserpin may Regulate Proteolytic Processing of Neuropeptides.' You mention a gene that is new to FlyBase, neuroserpin. Do you know which of the Genome Project CG annotations your gene corresponds to? All the CGs have corresponding gene records in FlyBase already and we don't like to make duplicate records for what is actually the same gene unless we can't avoid it. If your gene does not correspond to a CG then perhaps you could tell me its map location, as this is valuable information for the genome annotation project. Also, if neuroserpin has picked up a short symbol since you submitted the abstract then this would be a good time to tell me so I can get it into the database. Thank you very much for your help, with best wishes, Rachel. \---------------------------------------------------------------------- Rachel Drysdale, Ph.D. FlyBase (Cambridge), Department of Genetics, University of Cambridge, Downing Street, email: rd120@XXXXXXXXXXXXXXX Cambridge, CB2 3EH, Ph : 01223-333963 UK. FAX: 01223-333992 FlyBase: http://fly.ebi.ac.uk:7081/ \---------------------------------------------------------------------- From thomas.osterwalder@XXXXXXXXXXXXXXX Mon Mar 25 17:56:32 2002 To: Rachel Drysdale (Genetics) <rd120@XXXXXXXXXXXXXXX> Subject: Re: Helping FlyBase: ADRC-10845 Hi Rachel, sorry to be late with this reply. The Drosophila Neuroserpin like cDNA corresponds to sp4, CG9453, a serine proteinase inhibitor first described by Han et al (2000). One of the splice variants of this Serpin shows considerable homology to the vertebrate Neurosepin proteins (Human, mouse, rat, chicken). In the work I intend to present at the fly meeting, I used both, the Drosophila sp4 cDNA and a vertebrate (chicken) neuroserpin cDNA under the control of the GAL4 UAS to investigate mis/overexpression phenotypes. Since I found very similar phenotypes for overexpression of chicken Neuroserpin and Drosophila sp4, and because of the sequence similarity, I refer to the proteins in the title of my abstract as 'Neuroserpin'. Other features of vertebrate neuroserpin (like the neuron-specific expression) may be less conserved in flies, and I haven't found a bona-fide mutant yet (with a phenotype that would justify to name the gene), so I am reluctant to (re)name the gene and would probably stick with sp4 for right now. I hope this helped a little. Best, Thomas
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Language of Publication	English
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	Spn42Da