Reference Report

Reference
Citation	Suster, M.L., Bate, M. (2002). Embryonic assembly of a central pattern generator without sensory input. Nature 416(6877): 174--178. (Export to RIS)
FlyBase ID	FBrf0146852
Publication Type	Research paper
PubMed ID	11894094
PubMed Abstract	Locomotion depends on the integration of sensory information with the activity of central circuitry, which generates patterned discharges in motor nerves to appropriate muscles. Isolated central networks generate fictive locomotor rhythms (recorded in the absence of movement), indicating that the fundamental pattern of motor output depends on the intrinsic connectivity and electrical properties of these central circuits. Sensory inputs are required to modify the pattern of motor activity in response to the actual circumstances of real movement. A central issue for our understanding of how locomotor circuits are specified and assembled is the extent to which sensory inputs are required as such systems develop. Here we describe the effects of eliminating sensory function and structure on the development of the peristaltic motor pattern of Drosophila embryos and larvae. We infer that the circuitry for peristaltic crawling develops in the complete absence of sensory input; however, the integration of this circuitry into actual patterns of locomotion requires additional information from the sensory system. In the absence of sensory inputs, the polarity of movement is deranged, and backward peristaltic waves predominate at the expense of forward peristalsis.
DOI
Related Publication(s)
Review	Senseless motion. Marder, 2002, Nature 416(6877): 131--132 [FBrf0146851]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (1)
	Df(3L)S122804
Alleles (14)
	Ctet\TeTxLC^{IMPTNT-V.Scer\UAS} Ctet\TeTxLC^TNT.Scer\UAS Rcom\RA^Scer\UAS.cSa Scer\GAL4^12.1 Scer\GAL4^elav.PLu Scer\GAL4^elav-C155 Scer\GAL4^OK8 Scer\GAL4^OK72 Scer\GAL4^OK75 Scer\GAL4^OK83 Scer\GAL4^OK236 Scer\GAL4^OK259 Scer\GAL4^OK326 Scer\GAL4^P0206
Constructs (4)
	P{GAL4-elav.L} P{UAS-RA} P{UAS-TeTxLC.(-)V} P{UAS-TeTxLC.tnt}
Genes (3)
	Ctet\TeTxLC Rcom\RA Scer\GAL4
Insertions (10)
	P{GAL4}12.1 P{GAL4}OK8 P{GAL4}OK75 P{GAL4}OK83 P{GAL4}OK236 P{GAL4}OK259 P{GAL4}OK326 P{GAL4}P0206 P{GawB}elav^C155 P{GawB}OK72
Transcripts (9)
	Scer\GAL4^12.1RA Scer\GAL4^OK8RA Scer\GAL4^OK72RA Scer\GAL4^OK75RA Scer\GAL4^OK83RA Scer\GAL4^OK236RA Scer\GAL4^OK259RA Scer\GAL4^OK326RA Scer\GAL4^P0206RA