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Citation
Lecuit, T., Samanta, R., Wieschaus, E. (2002). slam Encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo.  Dev. Cell 2(4): 425--436.
FlyBase ID
FBrf0146973
Publication Type
Research paper
Abstract

Cellularization of the Drosophila embryo is a specialized form of cytokinesis that couples membrane growth with the formation of a polarized epithelium. We have identified a gene essential for polarized growth of the plasma membrane during cellularization. In slam mutant embryos, the furrow canal is disorganized, and polarized insertion of transmembrane proteins is disrupted. slam shows a striking developmental induction during the slow phase of cellularization, and Slam protein localizes to the furrow canal and the basal junction. Slam colocalizes with the junctional proteins Arm/beta-catenin, the PDZ domain-containing protein Dlt, and Myosin and is also required for their proper membrane localization. Our results suggest that developmental induction of Slam organizes the polarized growth of membrane via the recruitment of membrane-targeting proteins at adherens junctions.

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Related Publication(s)
Note

Cellular Morphogenesis. slow-as-molasses Accelerates Polarized Membrane Growth.
Beronja and Tepass, 2002, Dev. Cell 2(4): 382--384 [FBrf0146972]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (4)
    Alleles (4)
    Genes (13)
    Polypeptides (1)
    Experimental Tools (2)
    Transgenic Constructs (3)