Reference Report

Reference
Citation	Tazuke, S.I., Schulz, C., Gilboa, L., Fogarty, M., Mahowald, A.P., Guichet, A., Ephrussi, A., Wood, C.G., Lehmann, R., Fuller, M.T. (2002). A germline-specific gap junction protein required for survival of differentiating early germ cells. Development 129(10): 2529--2539. (Export to RIS)
FlyBase ID	FBrf0146994
Publication Type	Research paper
PubMed ID	11973283
PubMed Abstract	Germ cells require intimate associations and signals from the surrounding somatic cells throughout gametogenesis. The zero population growth (zpg) locus of Drosophila encodes a germline-specific gap junction protein, Innexin 4, that is required for survival of differentiating early germ cells during gametogenesis in both sexes. Animals with a null mutation in zpg are viable but sterile and have tiny gonads. Adult zpg-null gonads contain small numbers of early germ cells, resembling stem cells or early spermatogonia or oogonia, but lack later stages of germ cell differentiation. In the male, Zpg protein localizes to the surface of spermatogonia, primarily on the sides adjacent to the somatic cyst cells. In the female, Zpg protein localizes to germ cell surfaces, both those adjacent to surrounding somatic cells and those adjacent to other germ cells. We propose that Zpg-containing gap junctional hemichannels in the germ cell plasma membrane may connect with hemichannels made of other innexin isoforms on adjacent somatic cells. Gap junctional intercellular communication via these channels may mediate passage of crucial small molecules or signals between germline and somatic support cells required for survival and differentiation of early germ cells in both sexes.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(3L)CH12 Df(3L)CH20 Df(3L)ZN47
Alleles (17)
	Avic\GFP^Scer\UAS.cUa CG8368^t6.15 CG8368^zpg3 CG8368^zpg3-ex Scer\GAL4^ptc-559.1 w^+mC zpg¹ zpg² zpg³ zpg^3-ex zpg^+t6.15 zpg^z-0918 zpg^z-2533 zpg^z-2552 zpg^z-2679 zpg^z-3860 zpg^z-5352
Constructs (2)
	P{UAS-GFP.U} P{zpg^+t6.15}
Genes (18)
	Avic\GFP CG8368 Fas3 Inx2 Inx3 Inx5 Inx6 Inx7 ndl ogre ru Scer\GAL4 shakB shg vas w zpg α-Spec
Insertions (2)
	P{GawB}ptc^559.1 P{lacW}zpg³
Transcripts (1)
	zpg⁺R1.6