Reference Report

Reference
Citation	Ebner, A., Kiefer, F.N., Ribeiro, C., Petit, V., Nussbaumer, U., Affolter, M. (2002). Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Gene 287(1-2): 55--66. (Export to RIS)
FlyBase ID	FBrf0147036
Publication Type	Research paper
PubMed ID	11992723
PubMed Abstract	The development of the tracheal system of Drosophila melanogaster represents a paradigm for studying the molecular mechanisms involved in the formation of a branched tubular network. Tracheogenesis has been characterized at the morphological, cellular and genetic level and a series of successive, but linked events have been described as the basis for the formation of the complex network of tubules which extend over the entire organism. Tracheal cells stop to divide early in the process of tracheogenesis and the formation of the interconnected network requires highly controlled cell migration events and cell shape changes. A number of genes involved in these two processes have been identified but in order to obtain a more complete view of branching morphogenesis, many more genes carrying essential functions have to be isolated and characterized. Here, we provide a progress report on our attempts to identify further genes expressed in the tracheal system. We show that empty spiracles (ems), a head gap gene, is required for the formation of a specific tracheal branch, the visceral branch. We also identified a Sulfotransferase and a Multiple Inositol Polyphosphate phosphatase that are strongly upregulated in tracheal cells and discuss their possible involvement in tracheal development.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Gene
Title	Gene
Publication Year	1976-
ISBN/ISSN	0378-1119
Data from Reference
Aberrations (1)
	Df(3L)st7P
Alleles (11)
	brk^Scer\UAS.cJa dpp^Scer\UAS.cRa Ecol\lacZ^aft-22 Ecol\lacZ^{Hs6st-A201.1M3} Ecol\lacZ^Regio-3 Ecol\lacZ^trh-1-eve-1 ems² Hs6st^A201.1M3 put¹⁰⁴⁶⁰ Scer\GAL4^btl.PS UbcD10²²
Constructs (3)
	H{UAS-dpp.R} P{GAL4-btl.S} P{UAS-brk.J}
Genes (16)
	aft bnl brk Ccs CG5033 CG11866 dpp Ecol\lacZ ems gem Hs6st Mipp1 Pfk put Scer\GAL4 UbcD10
Insertions (4)
	P{ET-L}trh-1-eve-1 P{lab-lacZ.1:550.mHMG}UbcD10²² P{lacZ}Regio-3 P{lArB}Hs6st^A201.1M3