Reference Report

Reference
Citation	Giunta, K.L., Jang, J.K., Manheim, E.A., Subramanian, G., McKim, K.S. (2002). subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster. Genetics 160(4): 1489--1501. (Export to RIS)
FlyBase ID	FBrf0147060
Publication Type	Research paper
PubMed ID	11973304
PubMed Abstract	The female meiotic spindle lacks a centrosome or microtubule-organizing center in many organisms. During cell division, these spindles are organized by the chromosomes and microtubule-associated proteins. Previous studies in Drosophila melanogaster implicated at least one kinesin motor protein, NCD, in tapering the microtubules into a bipolar spindle. We have identified a second Drosophila kinesin-like protein, SUB, that is required for meiotic spindle function. At meiosis I in males and females, sub mutations affect only the segregation of homologous chromosomes. In female meiosis, sub mutations have a similar phenotype to ncd; even though chromosomes are joined by chiasmata they fail to segregate at meiosis I. Cytological analyses have revealed that sub is required for bipolar spindle formation. In sub mutations, we observed spindles that were unipolar, multipolar, or frayed with no defined poles. On the basis of these phenotypes and the observation that sub mutations genetically interact with ncd, we propose that SUB is one member of a group of microtubule-associated proteins required for bipolar spindle assembly in the absence of the centrosomes. sub is also required for the early embryonic divisions but is otherwise dispensable for most mitotic divisions.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (6)
	Df(2R)PC4 Df(2R)PC29 Df(2R)Pcl7B Df(2R)Pcl11B Df(2R)Pcl^XM82 Df(2R)RM2-1
Alleles (20)
	msps^MJ208 msps^P ncd¹ ncd^D nod⁴ sub¹ sub²² sub⁷² sub¹⁰⁴ sub¹³¹ sub^137D sub¹⁵⁸ sub²⁰² sub²¹⁸ sub¹⁷⁹⁴ sub^Dub tacc¹ wisp^12-3147 αTub67C¹ γTub37C¹
Genes (12)
	c CG10931 Ir54a msps ncd nod pr sub tacc wisp αTub67C γTub37C
Insertions (2)
	P{EP}sub^137D P{EP}sub^EP616