Reference Report

Reference
Citation	Ohshiro, T., Emori, Y., Saigo, K. (2002). Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Mech. Dev. 114(1-2): 3--11. (Export to RIS)
FlyBase ID	FBrf0147141
Publication Type	Research paper
PubMed ID	12175485
PubMed Abstract	Spatially and temporally regulated activity of Branchless/Breathless signaling is essential for trachea development in Drosophila. Early ubiquitous breathless (btl) expression is controlled by binding of Trachealess/Tango heterodimers to the btl minimum enhancer. Branchless/Breathless signaling includes a Sprouty-dependent negative feedback loop. We show that late btl expression is a target of Branchless/Breathless signaling and hence, Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells. Branchless/Breathless signaling activates MAP-kinase, which in turn, activates late btl expression and destabilizes Anterior-open, a repressor for late btl expression. Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (12)
	aop¹ aop^ACT.Scer\UAS bnl⁰⁰⁸⁵⁷ bnl^Scer\UAS.cSa btl^ΔOh10 Ecol\lacZ^btl.B3.M2 Ecol\lacZ^btl.B3 Ecol\lacZ^btl-ΔOh10 pnt^Δ88 Scer\GAL4^69B Scer\GAL4^btl.PS Scer\GAL4^ptc-559.1
Constructs (5)
	P{btl-lacZ.B3.M2} P{btl-lacZ.B3} P{GAL4-btl.S} P{UAS-aop.ACT} P{UAS-bnl.S}
Genes (7)
	aop bnl btl Ecol\lacZ pnt rl Scer\GAL4
Insertions (3)
	P{?lacW}btl^ΔOh10 P{GawB}69B P{GawB}ptc^559.1