Reference Report

Reference
Citation	Moreno, E., Basler, K., Morata, G. (2002). Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 416(6882): 755--759. (Export to RIS)
FlyBase ID	FBrf0147169
Publication Type	Research paper
PubMed ID	11961558
PubMed Abstract	During the growth of Drosophila imaginal discs a process called 'cell competition' eliminates slow-proliferating but otherwise viable cells. We report here that cell competition requires the function of the brinker (brk) gene, whose expression is normally repressed by Decapentaplegic (Dpp) signalling but is upregulated in slow-growing Minute/+ cells. Excess brk expression activates the c-Jun amino-terminal kinase pathway, which in turn triggers apoptosis in these cells. We propose that slow-proliferating cells upregulate Brk levels owing to a disadvantage in competing for, or in transducing, the Dpp survival signal. This sequence of events might represent a general mechanism by which weaker cells are eliminated from a growing population, and might serve as a method of controlling cell number and optimizing tissue fitness and hence organ function.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (3)
	T(1;2)sc^S2 Ts(1Lt;2Lt)sc^S2 Ts(1Rt;2Rt)sc^S2
Alleles (15)
	Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa brk^Scer\UAS.cJa brk^XH Ecol\lacZ^brk.min Ecol\lacZ^puc-E69 Ecol\lacZ^Scer\FRT.Ubx Ecol\lacZ^Ubx.PdC hep^r75 puc^Scer\UAS.cMa Rab5^{S43N.Scer\UAS} Scer\GAL4^dpp.blk1 Scer\GAL4^hh-Gal4 Scer\GAL4^Scer\FRT.Ubx Scer\GAL4^Ubx.PdC
Constructs (9)
	P{brk-lacZ.min} P{GAL4-dpp.blk1} P{GAL4-lacZ-Ubx(FRT.f⁺).dC} P{GAL4-lacZ-Ubx(-FRT).dC} P{UAS-brk.J} P{UAS-GFP.U} P{UAS-p35.H} P{UAS-puc.M} P{UAS-Rab5.S43N}
Genes (10)
	Avic\GFP BacA\p35 brk Ecol\lacZ en hep Mad puc Rab5 Scer\GAL4
Insertions (2)
	P{A92}puc^E69 P{GAL4}hh^Gal4