Reference Report

Reference
Citation	Choe, K.M., Werner, T., Stoven, S., Hultmark, D., Anderson, K.V. (2002). Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila. Science 296(5566): 359--362. (Export to RIS)
FlyBase ID	FBrf0147192
Publication Type	Research paper
PubMed ID	11872802
PubMed Abstract	Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (5)
	Df(3L)29A6 Df(3L)AC1 Df(3L)Rdl-2 Df(3R)ro-XB3 Df(3R)Tl-X
Alleles (14)
	Dif¹ Dredd^D55 Ecol\lacZ^Dpt.PR imd¹ ird5¹ PGRP-LA^dsRNA.cCa PGRP-LC¹ PGRP-LC² PGRP-LC^a.Scer\UAS PGRP-LC^dsRNA.cCa PGRP-LC^x.Scer\UAS Rel^E20 Scer\GAL4^c564 w^+mC
Constructs (3)
	P{Dipt2.2-lacZ} P{UAS-PGRP-LC.a} P{UAS-PGRP-LC.x}
Genes (20)
	AttA bol CecA1 Def Dif Dpt Dredd Drs Ecol\lacZ GluRIB imd ird5 Mtk PGRP-LA PGRP-LC Rdl Rel Scer\GAL4 Tequila w
Insertions (3)
	P{EP}EP3043 P{GawB}c564 P{PZ}bol¹