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Dobrosotskaya, I.Y., Seegmiller, A.C., Brown, M.S., Goldstein, J.L., Rawson, R.B. (2002). Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila.  Science 296(5569): 879--883.
FlyBase ID
FBrf0147193
Publication Type
Research paper
Abstract

Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.

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Note

Fats, flies, and palmitate.
Nohturfft and Losick, 2002, Science 296: 857--858 [FBrf0149184]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference