Reference Report

Reference
Citation	Milan, M., Perez, L., Cohen, S.M. (2002). Short-range cell interactions and cell survival in the Drosophila wing. Dev. Cell 2(6): 797--805. (Export to RIS)
FlyBase ID	FBrf0148949
Publication Type	Research paper
PubMed ID	12062091
PubMed Abstract	During development of multicellular organisms, cells are often eliminated by apoptosis if they fail to receive appropriate signals from their surroundings. Here, we report on short-range cell interactions that support cell survival in the Drosophila wing imaginal disc. We present evidence showing that cells incorrectly specified for their position undergo apoptosis because they fail to express specific proteins that are found on surrounding cells, including the LRR transmembrane proteins Capricious and Tartan. Interestingly, only the extracellular domains of Capricious and Tartan are required, suggesting that a bidirectional process of cell communication is involved in triggering apoptosis. We also present evidence showing that activation of the Notch signal transduction pathway is involved in triggering apoptosis of cells misspecified for their dorsal-ventral position.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(2L)32FP-5
Alleles (17)
	ap^rK568 ap^Scer\UAS.cMa BacA\p35^Scer\UAS.cHa Bx^{Scer\UAS.T:Ivir\HA1} caps^65.2 caps^ID.Scer\UAS caps^Scer\UAS.cSa fng^{Scer\UAS.B.T:Hsap\MYC} mam^EPgJ3-285 N^{ECN.Scer\UAS.cGa} salm^Scer\UAS.cBa Scer\GAL4^Act5C.PP Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} trn^S064117 trn^Scer\UAS.cMa trn^Δ2.9 trn^{ΔC.Scer\UAS.T:Hsap\MYC}
Constructs (12)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{UAS-ap.M} P{UAS-Bx.T:HA1} P{UAS-caps.ID} P{UAS-caps.S} P{UAS-fng.MYC.B} P{UAS-N.ECN.G} P{UAS-p35.H} P{UAS-salm.B} P{UAS-trn.M} P{UAS-trn.ΔC.MYC}
Genes (14)
	ap BacA\p35 bs Bx caps fng mam N salm Scer\GAL4 T:Hsap\MYC T:Ivir\HA1 trn wg
Insertions (3)
	P{EPg}mam^EPgJ3-285 P{lacW}trn^S064117 P{PZ}ap^rK568
Transcripts (1)
	trn^S064117RA