Reference Report

Reference
Citation	Smith, J.E., Cummings, C.A., Cronmiller, C. (2002). daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila. Development 129(13): 3255--3267. (Export to RIS)
FlyBase ID	FBrf0148972
Publication Type	Research paper
PubMed ID	12070099
PubMed Abstract	During Drosophila oogenesis two distinct stem cell populations produce either germline cysts or the somatic cells that surround each cyst and separate each formed follicle. From analyzing daughterless (da) loss-of-function, overexpression and genetic interaction phenotypes, we have identified several specific requirements for da(+) in somatic cells during follicle formation. First, da is a critical regulator of somatic cell proliferation. Also, da is required for the complete differentiation of polar and stalk cells, and elevated da levels can even drive the convergence and extension that is characteristic of interfollicular stalks. Finally, da is a genetic regulator of an early checkpoint for germline cyst progression: Loss of da function inhibits normally occurring apoptosis of germline cysts at the region 2a/2b boundary of the germarium, while da overexpression leads to postmitotic cyst degradation. Collectively, these da functions govern the abundance and diversity of somatic cells as they coordinate with germline cysts to form functional follicles.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Dp(2;2)da⁺20 Dp(2;Y)B231
Alleles (35)
	aop¹ aop² boss^unspecified brn^fs.107 brn^l.6P6 da² da⁷ da^hs.PSP da^lyh da^s22 drk^e0A Dsor1^S-1221 dx¹ dx^S1M Ecol\lacZ⁰¹³⁴⁴ Ecol\lacZ^how-B1-93F Ecol\lacZ^neur-A101 Egfr^f3 Egfr^t1 grk³ grk⁶ hh^hs.PI hop² phl⁷ pnt⁰⁷⁸²⁵ Ras85D^e1B rl^S-135 rl^Sem sev¹⁴ Sos^e4G spi¹ spi³ Stat92E⁰⁶³⁴⁶ Su(dx)² Su(H)¹
Constructs (2)
	P{HShh.I} P{hsp70-da⁺}
Genes (25)
	aop boss brn da drk Dsor1 dx Ecol\lacZ Egfr Fas3 grk hh hop hts phl pnt Ras85D rl sev Sos spi Stat92E Su(dx) Su(H) vas
Insertions (3)
	P{lacW}B1-93F P{lArB}neur^A101 P{PZ}l(3)01344⁰¹³⁴⁴