Open Close
Reference
Citation
De Gregorio, E., Spellman, P.T., Tzou, P., Rubin, G.M., Lemaitre, B. (2002). The Toll and Imd pathways are the major regulators of the immune response in Drosophila.  EMBO J. 21(11): 2568--2579.
FlyBase ID
FBrf0148976
Publication Type
Research paper
Abstract
Microarray studies have shown recently that microbial infection leads to extensive changes in the Drosophila gene expression programme. However, little is known about the control of most of the fly immune-responsive genes, except for the antimicrobial peptide (AMP)-encoding genes, which are regulated by the Toll and Imd pathways. Here, we used oligonucleotide microarrays to monitor the effect of mutations affecting the Toll and Imd pathways on the expression programme induced by septic injury in Drosophila adults. We found that the Toll and Imd cascades control the majority of the genes regulated by microbial infection in addition to AMP genes and are involved in nearly all known Drosophila innate immune reactions. However, we identified some genes controlled by septic injury that are not affected in double mutant flies where both Toll and Imd pathways are defective, suggesting that other unidentified signalling cascades are activated by infection. Interestingly, we observed that some Drosophila immune-responsive genes are located in gene clusters, which often are transcriptionally co-regulated.
PubMed ID
PubMed Central ID
PMC126042 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase
Microarray Normalization Protocol for De Gregorio et al.
Costello et al., 2008.9.10, Microarray Normalization Protocol for De Gregorio et al. [FBrf0205600]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference