Reference Report

Reference
Citation	Igaki, T., Kanda, H., Yamamoto-Goto, Y., Kanuka, H., Kuranaga, E., Aigaki, T., Miura, M. (2002). Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 21(12): 3009--3018. (Export to RIS)
FlyBase ID	FBrf0148977
Publication Type	Research paper
PubMed ID	12065414
PubMed Abstract	Drosophila provides a powerful genetic model for studying the in vivo regulation of cell death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis factor (TNF) superfamily ligand that can induce cell death. Eiger is a type II transmembrane protein with a C-terminal TNF homology domain. It is predominantly expressed in the nervous system. Genetic evidence shows that Eiger induces cell death by activating the Drosophila JNK pathway. Although this cell death process is blocked by Drosophila inhibitor-of-apoptosis protein 1 (DIAP1), it does not require caspase activity. We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (23)
	BacA\p35^Scer\UAS.cHa bsk² bsk^DN.Scer\UAS Ecol\lacZ^puc-E69 egr¹ egr³ egr^{dsRNA.Scer\UAS} egr^GS9830 egr^Scer\UAS.cIa egr^{Scer\UAS.T:Ivir\HA1} hep¹ Jra^IA109 msn¹⁷² Nc^{C318G.Scer\UAS} puc^E69 rpr^Scer\UAS.cIa Scer\GAL4^GMR.PF Scer\GAL4^hs.PB Scer\GAL4^sca-537.4 Scer\GAL4^vg.PM Tak1^{K46R.Scer\UAS} th⁴ th^{Scer\UAS.T:Ivir\HA1}
Constructs (12)
	P{GAL4-Hsp70.PB} P{GAL4-ninaE.GMR} P{GAL4-vg.M} P{GSV6} P{UAS-bsk.DN} P{UAS-dronc.C318G} P{UAS-eiger.I} P{UAS-eiger.IR} P{UAS-p35.H} P{UAS-rpr.I} P{UAS-Tak1.K46R} P{UAS-th.T:HA1}
Genes (15)
	BacA\p35 bsk Ecol\lacZ egr elav hep Jra msn Nc puc rpr Scer\GAL4 T:Ivir\HA1 Tak1 th
Insertions (3)
	P{A92}puc^E69 P{GawB}sca^537.4 P{GSV6}egr^GS9830