Reference Report

Reference
Citation	Johannes, B., Preiss, A. (2002). Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. Mech. Dev. 115(1-2): 3--14. (Export to RIS)
FlyBase ID	FBrf0149093
Publication Type	Research paper
PubMed ID	12049762
PubMed Abstract	Wing vein development in Drosophila is controlled by different morphogenetic pathways, including Notch. Hairless (H) antagonizes Notch target gene activation by binding to the Notch signal transducer Suppressor of Hairless [Su(H)]. Accordingly, overexpression of H phenocopies reduction of Notch activity. Deletion of the Su(H)-binding domain in H-C2 results in loss of H activity. However, overexpression of H-C2 induces formation of ectopic veins. In a screen for genetic modifiers of this phenotype, we have identified several genes involved in Notch and epidermal growth factor (EGF) signaling. Most notably veinlet, an activator of EGF signaling, acts downstream of H-C2. H-C2 positively regulates veinlet maybe through inhibition of inter-vein determinants in agreement with a model, whereby Notch and EGF signaling pathways cross-regulate vein pre-patterning.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (6)
	Df(1)N-54l9 Df(1)sc-B57 Df(3R)Dl-FX3 Df(3R)Espl22 Df(3R)P11 Df(3R)X10
Alleles (94)
	14-3-3ε^j2B10 ab² ab^k02807 ac¹ aop¹ ast¹ bib¹ boss⁴⁴ bs⁰³²⁶⁷ btl¹ chl¹ cno³ cno^ts cv¹ cv-c¹ cv-d¹ CycB3^L6540 da¹ da⁵ Dad^j1E4 dally⁰⁶⁴⁶⁴ dpp^d8 dpp^s1 dpp^s4 drk^k02401 dsr¹ dx²⁴ Dys^det-1 ec¹ Ecol\lacZ^rho-5 Ecol\lacZ^rho-X81 ed¹ Egfr^E1 Egfr^f6 Egfr^k05115 emc⁰⁴³²² emc^D flr³ ft^k07918 gro^E48 gro^E75 h²⁵ h²⁶ H^C2.hs H^C2.Scer\UAS H^hs.PM H^Scer\UAS.cMa H^wa heix^k11403 hv¹ kuz^k01403 lace² Mad¹² mam¹⁰ mam⁰⁴⁶¹⁵ N^55e11 N^264-10 N^Ax-E2 N^int.hs N^nd-1 N^nd-3 N^spl-1 net¹ neur¹¹ nub¹ nw² pnt¹ pnt⁰⁷⁸²⁵ px¹ rho⁵ rho^ve-1 rl¹ rn³ S⁵⁴ S^k09530 sax¹ sax² sc¹ sca¹ Scer\GAL4^Bx-MS1096 Scer\GAL4^en-e16E Ser^RX82 shn¹ Sos^k05224 spi¹ spi^s3547 Su(H)² Su(H)¹⁴ Su(H)¹⁶ th^j5C8 tkv⁸ vn¹ vvl^Zm γCop^S057302
Constructs (5)
	P{hs-H.C2} P{hs-H.FL} P{hsp70-Notch.intra} P{UAS-H.C2} P{UAS-H.M}
Genes (64)
	14-3-3ε ab ac aop ast bib boss bs btl chl cno cv cv-c cv-d CycB3 da Dad dally dpp drk dsr dx Dys ec Ecol\lacZ ed Egfr emc flr ft gro h H heix hv kuz lace Mad mam N net neur nub nw pnt px rho rl rn S sax sc sca Scer\GAL4 Ser shn Sos spi Su(H) th tkv vn vvl γCop
Insertions (4)
	P{en2.4-GAL4}e16E P{GawB}Bx^MS1096 P{lacW}rho⁵ P{lwB}X81
Transcripts (1)
	Ecol\lacZ^rho-5RA