Reference Report

Reference
Citation	Gritzan, U., Weiss, C., Brennecke, J., Bohmann, D. (2002). Transrepression of AP-1 by nuclear receptors in Drosophila. Mech. Dev. 115(1-2): 91--100. (Export to RIS)
FlyBase ID	FBrf0149096
Publication Type	Research paper
External Crossreferences
PubMed ID	12049770
PubMed Abstract	Mammalian cell culture studies have shown that several members of the nuclear receptor super family such as glucocorticoid receptor, retinoic acid receptor and thyroid hormone receptor can repress the activity of AP-1 proteins by a mechanism that does not require the nuclear receptor to bind to DNA directly, but that is otherwise poorly understood. Several aspects of nuclear receptor function are believed to rely on this inhibitory mechanism, which is referred to as transrepression. This study presents evidence that nuclear receptor-mediated transrepression of AP-1 occurs in Drosophila melanogaster. In two different developmental situations, embryonic dorsal closure and wing development, several nuclear receptors, including Seven up, Tailless, and Eagle antagonize AP-1. The inhibitory interactions with nuclear receptors are integrated with other modes of AP-1 regulation, such as mitogen-activated protein kinase signaling. A potential role of nuclear receptors in setting a threshold of AP-1 activity required for the manifestation of a cellular response is discussed.
BIOSIS ID	2002.405882
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Editors
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (24)
	EcR^B1.hs eg^18B eg^Mz360 eg^Scer\UAS.cDa Hr38^hs.11 Hr78^hs.PF kay¹ kay² kay^N.Scer\UAS kay^Scer\UAS.cEa kni² kni^Scer\UAS.cLa knrl^Scer\UAS.cLa puc^E69 rl^{Sem.C.Scer\UAS} Scer\GAL4^32B Scer\GAL4^pnr-MD237 Scer\GAL4^αTub84B.PL svp¹ svp^Scer\UAS.cKa tll¹ tll^hs.PS usp^hs.PO w^+mC
Constructs (13)
	P{hs-EcR.B1} P{hs-Hr38.11} P{hs-Hr78.F} P{HS-tll} P{hs-usp} P{tubP-GAL4} P{UAS-eg.D} P{UAS-Fra} P{UAS-kay.N} P{UAS-kni.L} P{UAS-knrl.L} P{UAS-rl^Sem} P{UAS-svp1.K}
Genes (14)
	EcR eg Hr38 Hr78 kay kni knrl puc rl Scer\GAL4 svp tll usp w
Insertions (2)
	P{GawB}32B P{GawB}pnr^MD237