Reference Report

Reference
Citation	Jackson, G.R., Wiedau-Pazos, M., Sang, T.K., Wagle, N., Brown, C.A., Massachi, S., Geschwind, D.H. (2002). Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34(4): 509--519. (Export to RIS)
FlyBase ID	FBrf0149139
Publication Type	Research paper
PubMed ID	12062036
PubMed Abstract	Pathologic alterations in the microtubule-associated protein tau have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD). Here, we show that tau overexpression, in combination with phosphorylation by the Drosophila glycogen synthase kinase-3 (GSK-3) homolog and wingless pathway component (Shaggy), exacerbated neurodegeneration induced by tau overexpression alone, leading to neurofibrillary pathology in the fly. Furthermore, manipulation of other wingless signaling molecules downstream from shaggy demonstrated that components of the Wnt signaling pathway modulate neurodegeneration induced by tau pathology in vivo but suggested that tau phosphorylation by GSK-3beta differs from canonical Wnt effects on beta-catenin stability and TCF activity. The genetic system we have established provides a powerful reagent for identification of novel modifiers of tau-induced neurodegeneration that may serve as future therapeutic targets.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (14)
	arm¹ arm⁴ arm^{S10.Scer\UAS.T:Hsap\MYC} BacA\p35^GMR.PH Hsap\MAPT^GMR.Ex.PJ Iap2^GMR.PH pan² pan^Scer\UAS.cWa Scer\GAL4^elav-C155 Scer\GAL4^hs.2sev Scer\GAL4^sev.EP sgg¹ sgg^Scer\UAS.cSa th^GMR.PH
Constructs (9)
	P{GAL4-Hsp70.sev} P{GMR-DIAP1} P{GMR-DIAP2} P{GMR-htau.Ex} P{GMRP35} P{sevEP-GAL4.B} P{UAS-arm.S10} P{UAS-pan.dTCF} P{UAS-sgg.S}
Genes (11)
	arm BacA\p35 elav Hsap\MAPT Iap2 Lam pan Scer\GAL4 sgg T:Hsap\MYC th
Insertions (3)
	P{GawB}elav^C155 P{GMR-htau.Ex}1.1 P{GMR-htau.Ex}2.1