Reference Report

Reference
Citation	Morales, J., Hiesinger, P.R., Schroeder, A.J., Kume, K., Verstreken, P., Jackson, F.R., Nelson, D.L., Hassan, B.A. (2002). Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34(6): 961--972. (Export to RIS)
FlyBase ID	FBrf0149142
Publication Type	Research paper
PubMed ID	12086643
PubMed Abstract	Mental retardation is a pervasive societal problem, 25 times more common than blindness for example. Fragile X syndrome, the most common form of inherited mental retardation, is caused by mutations in the FMR1 gene. Fragile X patients display neurite morphology defects in the brain, suggesting that this may be the basis of their mental retardation. Drosophila contains a single homolog of FMR1, dfxr (also called dfmr1). We analyzed the role of dfxr in neurite development in three distinct neuronal classes. We find that DFXR is required for normal neurite extension, guidance, and branching. dfxr mutants also display strong eclosion failure and circadian rhythm defects. Interestingly, distinct neuronal cell types show different phenotypes, suggesting that dfxr differentially regulates diverse targets in the brain.
DOI
Related Publication(s)
Review	Understanding fragile x syndrome. Insights from retarded flies. Gao, 2002, Neuron 34(6): 859--862 [FBrf0149141]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	Tp(3;2)by62
Alleles (9)
	Fmr1^EP3517 Fmr1^{I307N.Scer\UAS} Fmr1^Scer\UAS.cZa Fmr1^Δ50M Fmr1^Δ83M Fmr1^Δ113M Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^ato.3.6 Scer\GAL4^elav-C155
Constructs (4)
	P{ato-GAL4.3.6} P{UAS-Fmr1.I307N} P{UAS-Fmr1.Z} P{UAS-mCD8::GFP.L}
Genes (5)
	Fmr1 Mmus\Cd8a per Scer\GAL4 T:Avic\GFP
Insertions (2)
	P{EP}Fmr1^EP3517 P{GawB}elav^C155