Reference Report

Reference
Citation	Clark, I.E., Dobi, K.C., Duchow, H.K., Vlasak, A.N., Gavis, E.R. (2002). A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila. Development 129(14): 3325--3334. (Export to RIS)
FlyBase ID	FBrf0151259
Publication Type	Research paper
PubMed ID	12091303
PubMed Abstract	Translational repression of maternal nanos (nos) mRNA by a cis-acting Translational Control Element (TCE) in the nos 3'UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through ectopic expression experiments, that the nos TCE is capable of repressing gene expression at later stages of development in neuronal cells that regulate the molting cycle. Our results predict additional targets of TCE-mediated repression within the nervous system. They also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may function more widely during development to spatially or temporally control gene expression.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)Scf-R6
Alleles (22)
	Avic\GFP^Scer\UAS.cUa nos^{ΔB.αTub84B.3'UTR.nos+2.Scer\UAS} nos^{ΔB.αTub84B.3'UTR.Scer\UAS} nos^{αTub84B.3'UTR.nos+2.Scer\UAS} nos^{αTub84B.3'UTR.nosTCE.Scer\UAS} nos^{αTub84B.3'UTR.Scer\UAS} pum¹³ Scer\GAL4^Eh.2.4 Scer\GAL4^elav.PLu Scer\GAL4^GMR.PF Scer\GAL4^h-1J3 Scer\GAL4^HD23A Scer\GAL4^HD44A Scer\GAL4^how-24B Scer\GAL4^hs.2sev Scer\GAL4^insc-Mz1407 Scer\GAL4^KF42A Scer\GAL4^sca-109-68 Scer\GAL80^Eh.2.4 Scer\GAL80^αTub84B.PL smg¹ w^+mC
Constructs (12)
	P{Eh-GAL80.2.4} P{GAL4-Eh.2.4} P{GAL4-elav.L} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{tubP-GAL80} P{UAS-GFP.U} P{UAS-nos-tub3'UTR} P{UAS-nos-tub:nos+2} P{UAS-nos-tub:TCE} P{UAS-nosΔB-tub3'UTR} P{UAS-nosΔB-tub:nos+2}
Genes (8)
	Avic\GFP Eh nos pum Scer\GAL4 Scer\GAL80 smg w
Insertions (7)
	P{GAL4}HD23A P{GAL4}HD44A P{GAL4}KF42A P{GawB}h^1J3 P{GawB}how^24B P{GawB}insc^Mz1407 P{GawB}sca^109-68
Transcripts (4)
	Scer\GAL4^Eh.2.4RA Scer\GAL4^HD23ARA Scer\GAL4^HD44ARA Scer\GAL4^KF42ARA