Reference Report

Reference
Citation	Hannus, M., Feiguin, F., Heisenberg, C.P., Eaton, S. (2002). Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development 129(14): 3493--3503. (Export to RIS)
FlyBase ID	FBrf0151263
Publication Type	Research paper
PubMed ID	12091318
PubMed Abstract	We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (18)
	dsh¹ mts^{dn165.Scer\UAS} mts^{dn181.Scer\UAS} mts^{dn214.Scer\UAS} mts^Scer\UAS.cHa mts^XE-2202 mts^XE-2258 Scer\GAL4^ap-md544 Scer\GAL4^ptc-559.1 stan³ w^+mC wdb¹² wdb¹⁴ wdb^dn.Scer\UAS wdb^dw wdb^EP3559 wdb^IP wdb^Scer\UAS.cHa
Constructs (6)
	P{UAS-mts.dn165} P{UAS-mts.dn181} P{UAS-mts.dn214} P{UAS-mts.H} P{UAS-wdb.dn} P{UAS-wdb.H}
Genes (9)
	cora dsh fz mts PP2A-B' Scer\GAL4 stan w wdb
Insertions (3)
	P{EP}wdb^EP3559 P{GawB}ap^md544 P{GawB}ptc^559.1