Reference Report

Reference
Citation	Cavodeassi, F., Rodriguez, I., Modolell, J. (2002). Dpp signalling is a key effector of the wing-body wall subdivision of the Drosophila mesothorax. Development 129(16): 3815--3823. (Export to RIS)
FlyBase ID	FBrf0151271
Publication Type	Research paper
PubMed ID	12135920
PubMed Abstract	During development, the imaginal wing disc of Drosophila is subdivided along the proximal-distal axis into different territories that will give rise to body wall (notum and mesothoracic pleura) and appendage (wing hinge and wing blade). Expression of the Iroquois complex (Iro-C) homeobox genes in the most proximal part of the disc defines the notum, since Iro-C(-) cells within this territory acquire the identity of the adjacent distal region, the wing hinge. Here we analyze how the expression of Iro-C is confined to the notum territory. Neither Wingless signalling, which is essential for wing development, nor Vein-dependent EGFR signalling, which is needed to activate Iro-C, appear to delimit Iro-C expression. We show that a main effector of this confinement is the TGFbeta homolog Decapentaplegic (Dpp), a molecule known to pattern the disc along its anterior-posterior axis. At early second larval instar, the Dpp signalling pathway functions only in the wing and hinge territories, represses Iro-C and confines its expression to the notum territory. Later, Dpp becomes expressed in the most proximal part of the notum and turns off Iro-C in this region. This downregulation is associated with the subdivision of the notum into medial and lateral regions.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (25)
	Axn^A2.Scer\UAS brk^Scer\UAS.cJa Dad^Scer\UAS.cTa dpp^d12 dpp^d14 dpp^Scer\UAS.cCa Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^Scer\UAS.cUa pan^ΔN.Scer\UAS phl^{K497M.Scer\UAS} Ras85D^V12.Scer\UAS Scer\GAL4^Act5C.PI Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^C-765 Scer\GAL4^dpp.blk1 Scer\GAL4^MS248 Scer\GAL4^ptc-559.1 Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^tsh-md621 tkv⁴ tkv^{Q253D.Scer\UAS.cNb} vn^Scer\UAS.cSa wg^l-16 wg^l-17
Constructs (14)
	P{Act5C-GAL4} P{AyGAL4} P{BS3.0} P{GAL4-dpp.blk1} P{UAS-Axn.A2} P{UAS-brk.J} P{UAS-Dad.T} P{UAS-dpp.C} P{UAS-lacZ.U} P{UAS-pan.dTCFΔN} P{UAS-phl.KMRaf3.1} P{UAS-Ras85D.V12} P{UAS-tkv.Q253D.Nb} P{UAS-vn.S}
Genes (17)
	ara Axn brk caup Dad dpp Ecol\lacZ mirr nub pan phl Ras85D Scer\GAL4 tkv tsh vn wg
Insertions (6)
	P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}C-765 P{GawB}MS248 P{GawB}ptc^559.1 P{GawB}tsh^md621
Transcripts (1)
	Scer\GAL4^MS248RA