Reference Report

Reference
Citation	Kruger, O., Ladewig, J., Koster, K., Ragg, H. (2002). Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes. Gene 293(1-2): 97--105. (Export to RIS)
FlyBase ID	FBrf0151323
Publication Type	Research paper
PubMed ID	12137947
PubMed Abstract	By applying homology-search and text-mining programs we have found that the Drosophila serine protease inhibitor (serpin) gene sp4 harbours four reactive centre-coding exons. The mutually exclusive use of these cassettes in combination with alternatively selectable exons at the 5'-end or in the 3'-untranslated region of the gene allows generation of more than ten different transcripts, all of which are expressed in Drosophila embryos. These transcripts may code for eight different Sp4 protein isoforms with different biological functions, which - dependent on the splice pattern - either may be secreted, reside in the endoplasmic reticulum, or may be located in the cytoplasm. An examination revealed the presence of two serpin genes, each coding for two or three likely alternative reactive centre exon cassettes, respectively, also in the Caenorhabditis elegans genome. The occurrence of such serpin genes in some groups of metazoa reflects a parsimonious way to enlarge the adaptive ability of these organisms to cope with a plethora of different serine and cysteine proteases.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Gene
Title	Gene
Publication Year	1976-
ISBN/ISSN	0378-1119
Data from Reference
Genes (1)
	Spn42Da