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Citation
Bienz, M. (2002). The subcellular destinations of APC proteins.  Nat. Rev. Mol. Cell Biol. 3(5): 328--338.
FlyBase ID
FBrf0151433
Publication Type
Review
Abstract

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon, and is conserved in various organisms. Its best understood function is the destabilization of beta-catenin, a key effector of the Wnt signalling pathway. APC proteins are highly motile, and shuttle between several subcellular destinations. These destinations have prompted the discovery of new functions for the APC proteins, and this multitasking of APC might explain why its loss often leads to cancer.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Mol. Cell Biol.
    Title
    Nature Reviews. Molecular Cell Biology
    Publication Year
    2000-
    ISBN/ISSN
    1471-0072
    Data From Reference
    Genes (13)