Reference Report

Reference
Citation	Veraksa, A., Kennison, J., McGinnis, W. (2002). DEAF-1 function is essential for the early embryonic development of Drosophila. genesis 33(2): 67--76. (Export to RIS)
FlyBase ID	FBrf0151504
Publication Type	Research paper
PubMed ID	12112874
PubMed Abstract	The Drosophila protein DEAF-1 is a sequence-specific DNA binding protein that was isolated as a putative cofactor of the Hox protein Deformed (Dfd). In this study, we analyze the effects of loss or gain of DEAF-1 function on Drosophila development. Maternal/zygotic mutations of DEAF-1 largely result in early embryonic arrest prior to the expression of zygotic segmentation genes, although a few embryos develop into larvae with segmentation defects of variable severity. Overexpression of DEAF-1 protein in embryos can induce defects in migration/closure of the dorsal epidermis, and overexpression in adult primordia can strongly disrupt the development of eye or wing. The DEAF-1 protein associates with many discrete sites on polytene chromosomes, suggesting that DEAF-1 is a rather general regulator of gene expression.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	genesis
Title	genesis
Publication Year	2000-
ISBN/ISSN	1526-954X 1526-968X
Data from Reference
Aberrations (2)
	Df(3L)25-21 Df(3L)kto2
Alleles (18)
	cyc^t19 Deaf1^+t19 Deaf1^k3 Deaf1^S10B Deaf1^Scer\UAS.cVa Deaf1^unspecified Fibp^t19 Pc⁴ Scer\GAL4^69B Scer\GAL4^A9 Scer\GAL4^arm.PS Scer\GAL4^Bx-MS1096 Scer\GAL4^Dll-md23 Scer\GAL4^dpp.blk1 Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^sca-537.4 trc^t19
Constructs (6)
	P{C4D1R} P{GAL4-arm.S} P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{UAS-Deaf1.V}
Genes (28)
	Ars2 Bzd CG1815 CG8003 CG8503 CG8569 CG9684 CG9925 CG11253 CG14590 CG18136 cyc Cyp305a1 Deaf1 Dfd Fibp ftz Hph kni Kr kto nvy Papss Pc RAF2 Scer\GAL4 trc Zfrp8
Insertions (6)
	P{GAL4}A9 P{GawB}69B P{GawB}Bx^MS1096 P{GawB}Dll^md23 P{GawB}sca^537.4 P{lacW}l(3)L0189^L0189
Natural transposons (2)
	412 roo