Reference Report

Reference
Citation	DiBartolomeis, S.M., Akten, B., Genova, G., Roberts, M.A., Jackson, F.R. (2002). Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin. Mol. Genet. Genomics 267(5): 564--576. (Export to RIS)
FlyBase ID	FBrf0151697
Publication Type	Research paper
PubMed ID	12172795
PubMed Abstract	Mutations in the Drosophila miniature-dusky ( m-dy) gene complex were first reported by Morgan and Bridges about 90 years ago. m-dy mutants have abnormally small wings, a phenotype attributed to a cell-autonomous reduction in the size of the epidermal cells comprising the differentiated wing. Using a molecular genetic approach, we have characterized the m-dy chromosomal interval and identified a pair of adjacent transcription units corresponding to m and dy. A dy mutant known as dy (And) has a single base substitution within the protein-coding region that is predicted to result in an amber stop codon and premature translational termination. We show that dy mRNA is expressed at two discrete periods during the life cycle--one during embryonic development and early larval instars, the second during adult development, coincident with wing differentiation. In agreement with the phenotypic similarity of m and dy mutants, sequence comparisons reveal a similarity between the predicted MINIATURE and DUSKY proteins, and indicate that the m and dy genes are members of a larger Drosophila gene family. Both m and dy, as well as other members of this superfamily, are predicted to encode transmembrane proteins with similarity to C. elegans cuticle proteins known as cuticulins. We postulate that m, dy and other members of this protein superfamily function as structural components of the Drosophila cuticulin layer. Such a role for m and dy products in wing differentiation is sufficient to explain the morphological phenotypes associated with m-dy mutants.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Genet. Genomics
Title	Molecular Genetics and Genomics
Publication Year	2001-
ISBN/ISSN	1617-4615
Data from Reference
Aberrations (7)
	Df(1)KA6 Df(1)m-30 Df(1)m259-4 Df(1)m-MR Df(1)RA47 Dp(1;Y)y⁺v⁺#3 Tp(1;3)v⁺74c
Alleles (8)
	dy¹ dy⁷³ dy^Q189stop m¹ m^38c m^259-4 m^MR m^mw
Genes (7)
	anon-10Eb CG15020 CG15223 dy dyl m zye
Insertions (1)
	Doc{}dy⁷³
Transcripts (1)
	dy-R4.2